Table 1. Demographic, clinical and MRI data.
| Low-grade PVHs (without or mild) (n=80) | High-grade PVHs (moderate) (n=16) | P | Low-grade DWMHs (without or mild) (n=80) | High-grade DWMHs (moderate) (n=16) | P | |
|---|---|---|---|---|---|---|
| Age (years)a | 59.48 (3.48) | 61.00 (2.48) | 0.10 | 59.48 (3.35) | 61.00 (3.25) | 0.10 |
| Sex (n (%) female)b | 48 (60.0) | 9 (56.3) | 0.78 | 48 (60.0) | 9 (56.3) | 0.78 |
| Education (years)c | 8 (6–9) | 8 (6.25–10) | 0.71 | 8 (6–10) | 8 (6.25–8.75) | 0.98 |
| MMSEc | 29 (28–30) | 30 (28.25–30) | 0.20 | 29 (28–30) | 30 (28–30) | 0.71 |
| Vocabulary (WAIS-III)a | 38.91 (8.76) | 37.56 (10.56) | 0.59 | 39.36 (8.85) | 37.50 (9.47) | 0.50 |
| GDS-15c | 2 (1–3) | 1 (0–2) | 0.08 | 2 (0–3) | 1 (1–2.75) | 0.89 |
| REGICORc | 5 (4–7) | 6.5 (4.25–8.5) | 0.26 | 5 (4–7) | 6.5 (4.25–8) | 0.32 |
| Vascular risk factors (n (%)) | ||||||
| Hypertensionb | 38 (47.5) | 7 (43.8) | 0.78 | 34 (42.5) | 11 (68.8) | 0.04* |
| Dyslipidemiab | 48 (60.0) | 9 (56.3) | 0.78 | 47 (58.8) | 10 (62.5) | 0.78 |
| DMd | 15 (18.8) | 2 (12.5) | 0.73 | 15 (18.8) | 2 (12.5) | 0.73 |
| Current smokerd | 12 (15.0) | 3 (18.8) | 0.71 | 13 (16.3) | 2 (12.5) | 1 |
| MRI measuresa | ||||||
| GM (cm3) | 590.82 (35.38) | 580.80 (45.11) | 0.41 | 586.12 (36.22) | 581.74 (45.14) | 0.72 |
| WM (cm3) | 564.90 (60.69) | 542.24 (63.28) | 0.19 | 543.56 (55.53) | 546.50 (64.83) | 0.87 |
| BP (cm3) | 1,155.72 (93.52) | 1,123.04 (104.70) | 0.25 | 1,129.68 (88.42) | 1,128.24 (106.39) | 0.96 |
| TBV (cm3) | 1,450.51 (118.78) | 1,420.00 (128.76) | 0.38 | 1,424.18 (109.25) | 1,425.27 (130.96) | 0.98 |
| Ratio GM/TBV (%) | 40.97 (1.73) | 40.83 (1.35) | 0.73 | 41.22 (1.51) | 40.89 (1.39) | 0.38 |
| Ratio WM/TBV (%) | 38.74 (1.55) | 38.25 (1.50) | 0.27 | 38.11 (1.51) | 38.27 (1.54) | 0.71 |
| Ratio BP/TBV (%) | 79.71 (2.03) | 79.08 (1.44) | 0.25 | 79.33 (1.80) | 79.16 (1.52) | 0.67 |
| LI present (n (%))d | 4 (5.1) | 3 (18.8) | 0.09 | 6 (7.5) | 1 (6.3) | 1 |
BP, brain parenchymal volume=GM+WM; DM, diabetes mellitus; DWMHs, deep white matter hyperintensities; GDS-15, geriatric depression scale, 15-item version; GM, gray matter volume; LI, lacunar infarcts; MMSE, mini-mental state examination; MRI, magnetic resonance imaging; PVHs, periventricular hyperintensities; REGICOR, Registre Gironí del Cor; TBV, total brain volume; WAIS-III, Wechsler Adult Intelligence Scale 3rd edition; WM, white matter volume.
Values are means (s.d.) in Student's t-test or medians (interquartile range) in Mann–Whitney test for continuous variables. Values are n (%) for categorical variables in χ2 test and Fisher's exact test. P shows statistical comparison between participants with high-grade and low-grade white matter lesions.
*P<0.05.
Student's t-test.
χ2 test.
Mann–Whitney test.
Fisher's exact test.