Table 1. Regional kinetic parameter (mean±SD) of seven subjects obtained with a 2-TCM using full length of scan data (90 minutes).
| K1 (mL/min per mL) | K1/k2 (mL/cm3) | k3 (1/min) | k4 (1/min) | BPND | VS (mL/cm3) | VT (mL/cm3) | |
|---|---|---|---|---|---|---|---|
| Cerebellar ctx. | 0.48±0.06 (2±1) | 4.36±0.75 (11±3) | 0.14±0.03 (15±5) | 0.035±0.005 (8±3) | 4.2±1.2 (13±4) | 18.0±3.7 (4±1) | 22.4±3.9 (3±1) |
| Temporal ctx. | 0.54±0.09 (2±0) | 4.15±0.94 (9±3) | 0.24±0.05 (9±4) | 0.033±0.005 (4±2) | 7.4±2.1 (9±4) | 29.1±4.3 (2±1) | 33.3±4.4 (2±1) |
| Frontal ctx. | 0.53±0.10 (2±1) | 4.33±1.07 (11±5) | 0.25±0.07 (13±7) | 0.036±0.005 (5±3) | 7.2±3.0 (13±6) | 28.7±4.1 (2±1) | 33.0±4.0 (2±1) |
| Caudate head | 0.51±0.09 (6±3) | 10.05±6.94 (63±28) | 0.32±0.26 (73±46) | 0.039±0.013 (31±13) | 9.9±10.4 (74±39) | 49.1±11.0 (14±13) | 59.2±9.7 (7±3) |
| Putamen | 0.57±0.08 (4±1) | 6.48±2.59 (31±12) | 0.29±0.12 (33±16) | 0.036±0.007 (14±6) | 8.7±5.4 (35±15) | 45.7±8.5 (6±3) | 52.2±7.7 (4±2) |
| Thalamus | 0.59±0.05 (5±2) | 6.38±3.86 (35±14) | 0.37±0.24 (35±16) | 0.034±0.007 (16±7) | 12.6±10.7 (39±15) | 48.8±8.2 (6±4) | 55.2±7.0 (4±2) |
| Anterior cingulate | 0.49±0.08 (5±1) | 3.88±2.51 (32±14) | 0.37±0.15 (31±21) | 0.033±0.009 (13±6) | 12.7±7.5 (35±19) | 36.3±6.0 (6±5) | 40.2±5.7 (4±1) |
| Pons | 0.39±0.06 (5±2) | 4.58±1.94 (35±14) | 0.25±0.15 (38±15) | 0.032±0.005 (17±6) | 8.1±5.1 (39±15) | 28.9±7.3 (7±3) | 33.4±7.9 (6±2) |
2-TCM; two-tissue compartment model; BPND, binding potential; COV, coefficient of variation.
Each subject was scanned twice. Values between parentheses indicate the identifiability (%COV) of the parameters.