Table 2. Reproducibility of [11C]SL25.1188 total distribution volume (V T), distribution volume of the specifically bound radiotracer (V S) and binding potential (BPND) derived via 2-TCM.
| 90 minutes data |
VT
(mL/cm3) |
VS
(mL/cm3) |
BPND |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean | BSSD (%CV) | WSSD (%CV) | TRV±SD (%) | ICC | Mean | BSSD (%CV) | WSSD (%CV) | TRV±SD (%) | ICC | Mean | BSSD (%CV) | WSSD (%CV) | TRV±SD (%) | ICC | |
| Cerebellar ctx. | 22.4 | 5.3 (23) | 2.0 (9) | 11±7 | 0.739 | 18 | 5.1 (28) | 1.8 (10) | 12±10 | 0.771 | 4.2 | 1.3 (30) | 1.1 (25) | 28±17 | 0.18 |
| Temporal ctx. | 33.3 | 5.4 (16) | 3.4 (10) | 12±9 | 0.438 | 29.1 | 5.3 (18) | 3.2 (11) | 12±12 | 0.471 | 7.4 | 2.2 (30) | 2.0 (27) | 28±25 | 0.109 |
| Prefrontal ctx. | 33 | 4.7 (14) | 3.2 (10) | 11±9 | 0.379 | 28.7 | 5.3 (19) | 2.7 (9) | 11±10 | 0.6 | 7.2 | 3.5 (48) | 2.5 (35) | 28±24 | 0.303 |
| Caudate head | 59.2 | 11.8 (20) | 7.4 (12) | 15±6 | 0.442 | 49.1 | 15.1 (31) | 5.4 (11) | 14±12 | 0.77 | 9.9 | 9.6 (97) | 11.1 (112) | 97±50 | −0.146 |
| Putamen | 52.2 | 9.5 (18) | 5.8 (11) | 13±9 | 0.457 | 45.7 | 10.9 (24) | 5.8 (13) | 14±11 | 0.559 | 8.7 | 6.7 (77) | 3.9 (45) | 38±27 | 0.497 |
| Thalamus | 55.2 | 9.1 (16) | 4.4 (8) | 10±7 | 0.615 | 48.8 | 11.4 (23) | 3.8 (8) | 9±10 | 0.796 | 12.6 | 14.7 (116) | 5.4 (42) | 39±20 | 0.765 |
| Ant cingulate ctx. | 40.2 | 7.0 (17) | 4.3 (11) | 13±10 | 0.445 | 36.3 | 7.3 (20) | 4.6 (13) | 16±11 | 0.442 | 12.7 | 10.5 (83) | 3.2 (25) | 31±27 | 0.83 |
| Pons | 33.4 | 11.1 (33) | 3.1 (9) | 11±9 | 0.856 | 28.9 | 10.3 (36) | 3.0 (10) | 13±10 | 0.84 | 8.1 | 3.2 (40) | 6.2 (77) | 69±58 | −0.577 |
BSSD, between-subject standard deviation; CV, %standard deviation/mean; TRV, the mean across the subjects of the ratio absolute value of the difference between measurements to average of the measurements; ICC, intraclass correlation coefficient; WSSD, within-subject standard deviation.