Table 5.
Suzuki-Miyaura Couplings Reactions: Nok vs. TPGS-750-M
| ||||||
|---|---|---|---|---|---|---|
| Entry | Aryl halide | Boronic acid | Product | TPGS-750-Ma yield(%) | Noka yield(%) | Time (h) |
| 1 |
|
|
|
99 | 99 | 2 |
| 2 |
|
|
|
94 | 99 | 2 |
| 3 |
|
|
|
90 | 95 | 4 |
| 4 |
|
|
|
94 | 99 | 4 |
Isolated yields of chromatographically pure materials; reaction conditions: alkyl bromide (0.5 mmol, 1 equiv), boronic acid (0.75–1.00 mmol), triethylamine (3 equiv), catalyst Pd(dtbpf)Cl2 (2 mol %), and 2 wt % of surfactant/H2O.