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. 2014 May 1;3:6. doi: 10.1186/2046-2395-3-6

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Copyright © 2014 Dai et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Echocardiography of cardiac aging in wild-type (WT) and mCAT mice (A-D) and Polg^m/mmice in the presence or absence of mCAT (E-H). (A, E) Left ventricular mass index (LVMI), (B, F) % FS (fractional shortening), (C, G) Ea/Aa by tissue Doppler imaging (diastolic function), (D, H) the myocardial performance index (MPI). The increased linear trends across ages in WT mice were significant for all parameters (P <0.05 for all, left panels). The beneficial effect of mCAT versus WT was analyzed by the interaction between genotype and the linear age trend, and was significant in all cases (P <0.01 for all except fractional shortening, P = 0.03). *P <0.05 versus Polg^m/m at age 4 to 6 months, #P <0.05 versus Polg^m/m at age 13 to 14 months (right panels). LVMI, Left ventricular mass index; mCAT, catalase targeted to mitochondria. Modified from Dai et al. [25,43].