Table 2.

Immune phenotypes in the nursing home elderly compared to healthy adults

Immune phenotype	Nursing home elderly	Healthy adults	p-value*
	Median (IQR)	Median (IQR)
	n = 262	n = 16
CD8+
CD8 + %	17.1 (11.9 – 23.9)	18.0 (15.1 – 21.0)	0.56
Naïve CD8 + %	0.90 (0.5 – 1.4)	5.2 (3.8 – 7.9)	<0.001
Central memory CD8 + %	0.6 (0.3 – 1.0)	0.5 (0.4 – 0.8)	0.86
Effector memory CD8 + %	6.3 (3.9 – 9.4)	8.1 (6.6 – 10.1)	0.14
Terminally differentiated CD8 + %	7.3 (3.5 – 12.5)	4.1 (2.0 – 6.0)	0.004
Senescent CD8 + %	5.3 (2.2 – 9.4)	3.1 (0.7 – 6.2)	0.04
CD4+
CD4 + %	45.5 (38.0 - 52.7)	37.1 (29.7 - 43.1)	0.001
Naïve CD4 + %	9.2 (5.1 – 13.7)	11.6 (7.1 - 15.4)	0.19
Central memory CD4 + %	12.6 (9.1 - 16.2)	8.4 (6.5 - 13.2)	0.003
Effector memory CD4 + %	18.6 (14.1 - 22.6)	12.3 (11.8 - 15.8)	<0.001
Terminally differentiated CD4 + %	1.8 (1.1 – 2.8)	1.2 (0.6 - 2.1)	0.09
Senescent CD4 + %	1.4 (0.2 - 3.4)	0.8 (0.1-2.0)	0.21
T-reg
T-reg%	1.8 (1.1 – 2.6)	0.8 (0.6 – 0.9)	<0.001
Ratio
CD4 + : CD 8 + ratio	2.6 (1.7 – 4.1)	1.9 (1.6 – 2.6)	0.048
NK
Mature NK cell%	12.1 (7.9 – 16.6)	5.4 (2.7 – 10.0)	0.001
Senescent NK cell%	1.4 (0.89 – 2.2)	1.7 (1.5 – 2.6)	0.27
Immature NK cell%	0.2 (0.1 – 0.4)	0.3 (0.04 – 0.7)	0.57

*Mann–Whitney U test of significance used.