Table 3.
Immune phenotypes as a function of age, sex, frailty and nutritional status
|
Immune phenotype |
Age Correlation
+
(r) n = 262 |
Sex Median (IQR
) n = 262
++
|
Clinical Frailty Scale Median (IQR) n = 262
+++
|
Nutritional Status Median (IQR) n = 261
a+++
|
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Female n = 213 | Male n = 49 | 4 n = 64 | 5 n = 62 | 6 n = 94 | 7 or 8 n = 42 | Normal n = 127 | At risk n = 121 | Mal-nourished n = 13 | ||
| CD8+ | ||||||||||
| CD8 + % |
0.05 |
17.1 |
17.4 |
18.6 |
17.6 |
16.3 |
16.3 |
17.4 |
17.1 |
17.1 |
| (11.8-24.2) |
(12.8-22.2) |
(13.7-23.8) |
(12.3-21.9) |
(11.7-24.1) |
(9.7-26.8) |
(12.2-23.8) |
(11.7-24.2) |
(11.2-20.9) |
||
| Naïve CD8 + % |
−0.13* |
0.9 |
0.8 |
0.9 |
0.8 |
1.0 |
1.2 |
0.9 |
1.0 |
0.7 |
| (0.5-1.5) |
(0.4-1.2) |
(0.5-1.4) |
(0.5-1.4) |
(0.5-1.4) |
(0.5-2.1) |
(0.5-1.4) |
(0.58-1.6) |
(0.3-1.2) |
||
| Central memory CD8 + % |
−0.03 |
0.6 |
0.5 |
0.5 |
0.5 |
0.6 |
0.7 |
0.5 |
0.7 |
0.5 |
| (0.3-1.0) |
(0.3-0.8) |
(0.3-0.9) |
(0.3-0.9) |
(0.3-1.0) |
(0.3-1.5) |
(0.3-0.9) |
(0.3-1.1) |
(0.4-0.9) |
||
| Effector memory CD8 + % |
−0.04 |
6.1 |
7.1 |
6.7 |
6.3 |
6.3 |
5.7 |
6.5 |
6.0 |
6.0 |
| (3.8-9.5) |
(4.5-9.7) |
(4.1-9.9) |
(4.1-8.7) |
(3.7-10.0) |
(4.0-8.6) |
(3.8-9.9) |
(3.9-8.8) |
(4.0-10.9) |
||
| Terminally differentiated CD8 + % |
0.08 |
7.8 |
5.9 |
8.9 |
7.6 |
6.9 |
6.1 |
8.1 |
7.2 |
5.8 |
| (3.6-12.6) |
(3.3-12.5) |
(4.2-13.3) |
(3.7-12.8) |
(3.4-11.0) |
(2.4-12.9) |
(3.5-12.7) |
(3.6-12.5) |
(3.1-10.9) |
||
| Senescent CD8 + % |
0.04 |
5.1 |
5.7 |
6.2 |
5.0 |
5.1 |
4.9 |
5.1 |
5.2 |
5.6 |
| (2.3-8.9) |
(2.0-11.3) |
(2.8-11.4) |
(2.3-9.3) |
(2.2-7.9) |
(0.8-10.0) |
(2.2-10.0) |
(2.3-8.6) |
(1.2-9.5) |
||
| CD4+ | ||||||||||
| CD4 + % |
−0.06 |
46.1* |
42.1* |
44.9 |
45.8 |
46.4 |
43.1 |
46.1 |
45.8 |
42.0 |
| (39.1-53.8) |
(34.7-49.1) |
(38.6-53.6) |
(37.1-52.6) |
(40.4-53.1) |
(32.4-52.7) |
(38.7-52.6) |
(36.1-53.5) |
(35.9-44.9) |
||
| Naïve CD4 + % |
0.05 |
10.1* |
7.1* |
10.5 |
9.2 |
9.3 |
7.2 |
10.4* |
8.7* |
5.9* |
| (5.4-14.6) |
(4.6-11.5) |
(5.4-18.0) |
(5.3-14.7) |
(5.4-13.1) |
(4.0-12.2) |
(5.4-16.1) |
(4.8-12.5) |
(3.4-9.9) |
||
| Central memory CD4 + % |
−0.08 |
12.8 |
11.7 |
12.5 |
12.0 |
13.3 |
12.8 |
12.5 |
13.1 |
10.7 |
| (9.6-16.4) |
(8.7-14.6) |
(9.0-15.4) |
(8.4-16.2) |
(10.7-18.2) |
(8.7-15.8) |
(9.2-16.2) |
(9.0-17.2) |
(9.3-13.3) |
||
| Effector memory CD4 + % |
0.13* |
18.9 |
18.2 |
19.3 |
18.1 |
19.2 |
17.0 |
18.6 |
19.0 |
18.5 |
| (14.6-23.0) |
(12.9-21.4) |
(13.6-21.8) |
(12.7-21.9) |
(15.2-24.2) |
(13.5-22.4) |
(13.5-21.8) |
(14.6-22.8) |
(12.8-26.6) |
||
| Terminally differentiated CD4 + % |
0.05 |
1.9* |
1.4* |
1.9 |
1.8 |
1.6 |
1.8 |
1.9 |
1.6 |
1.4 |
| (1.1-2.9) |
(0.6-2.5) |
(1.1-3.3) |
(1.1-2.6) |
(1.1-2.7) |
(0.8-2.7) |
(1.1-2.9) |
(1.0-2.8) |
(0.9-2.0) |
||
| Senescent CD4 + % |
0.11 |
1.4 |
1.3 |
1.5 |
1.4 |
1.4 |
1.2 |
1.4 |
1.3 |
2.0 |
| (0.3-3.5) |
(0.2-2.9) |
(0.3-4.2) |
(0.1-3.1) |
(0.3-3.6) |
(0.2-2.9) |
(0.16-3.4) |
(0.27-3.2) |
(0.34-4.4) |
||
| T-reg | ||||||||||
| T-reg% |
0.08 |
1.8 |
1.6 |
2.5 ** |
2.0** |
1.6** |
1.0** |
2.2** |
1.6** |
1.0** |
| (1.2-2.6) |
(0.9-2.6) |
(1.8-2.9) |
(1.3-2.6) |
(1.1-2.3) |
(0.8-1.5) |
(1.5-2.9) |
(1.1-2.3) |
(0.8-1.2) |
||
| Ratio |
|
|||||||||
| CD4 + : CD 8 + ratio |
−0.06 |
2.6 |
2.5 |
2.5 |
2.4 |
2.7 |
2.6 |
2.6 |
2.6 |
2.3 |
| (1.7-4.5) |
(1.6-3.5) |
(1.6-3.8) |
(1.8-4.1) |
(1.9-4.5) |
(1.4-5.0) |
(1.7-4.1) |
(1.6-4.5) |
(1.8-3.3) |
||
| NK | ||||||||||
| Mature NK cell% |
−0.05 |
12 |
12.6 |
12.0 |
11.3 |
12.3 |
12.7 |
12.3 |
11.6 |
14.7 |
| (8.0-16.6) |
(7.1-17) |
(8.3-6.3) |
(7.1-15.2) |
(7.3-16.7) |
(8.5-17.2) |
(8.7-16.0) |
(6.8-16.5) |
(7.9-18.4) |
||
| Senescent NK cell% |
−0.10 |
1.4 |
1.5 |
1.0** |
1.1** |
1.7** |
2.0** |
1.3* |
1.6* |
1.4* |
| (0.9-2.2) |
(1.0-2.4) |
(0.7-1.9) |
(0.7-1.9) |
(1.0-2.7) |
(1.3-2.7) |
(0.74-2.1) |
(1.0-2.7) |
(1.1-2.3) |
||
| Immature NK cell% | 0.03 | 0.2 |
0.3 |
0.2 |
0.21 |
0.3 |
0.3 |
0.2 |
0.2 |
0.2 |
| (0.1-0.4) | (0.1-0.5) | (0.1-0.4) | (0.1-0.3) | (0.2-0.4) | (0.2-0.4) | (0.2-0.4) | (0.1-0.4) | (0.13-0.45) | ||
*p ≤ 0.05.
**p ≤ 0.001.
aOne patient excluded as nutritional status unknown.
+Spearman’s rank test of significance used.
++Mann–Whitney U test of significance used.
+++Kruskal-Wallis test of significance used.