. Author manuscript; available in PMC: 2015 Apr 15.

Published in final edited form as: Biochem Pharmacol. 2014 Jan 21;88(4):450–467. doi: 10.1016/j.bcp.2014.01.011

Table 3.

Approved Alzheimer’s disease drugs found to ameliorate cognitive deficits in Alzheimer’s disease mouse models

Compound	Action	Behavioral Task(s)	Model(s) Tested	Reference
Memantine	NMDAR antagonist	FC, MWM	3xTg-AD	Martinez-Coria et al., 2010 [313]
		MWM	APP/PS1	Minkeviciene et al., 2004 [314]
		MWM	APP (APP23)	Van Dam et al., 2005; Van Dam and De deyn, 2006 [315,316]
		MWM	APP (Tg2576)	Chen et al., 2010 [317]
		FC	Ts65Dn (Down syndrome mouse)	Costa et al., 2008 [318]
Donepezil	AChE inhibitor	FC	intracerebroventricular Aβ injection	Tsunekawa et al., 2008 [319]
		FC	APP (Tg2576)	Dong et al., 2005 [185]
		MWM	APP (APP23)	Van Dam et al., 2005; Van Dam et al., 2008 [315,320]
Donepezil, Memantine		MWM	APP/PS1	Nagakura et al., 2013 [321]
Galantamine	AChE inhibitor, nAChR modulator	FC	intracerebroventricular Aβ injection	Wang et al., 2007 [322]
		MWM	intracerebroventricular Aβ injection	Takeda et al., 2009 [323]
		MWM	APP (APP23)	Van Dam et al., 2005; Van Dam and De deyn, 2006 [315,316]