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. 2012 Nov 7;32(45):15715–15727. doi: 10.1523/JNEUROSCI.2841-12.2012

Figure 8.

Figure 8.

Effects of intravitreal injection of CNTF on photoreceptor injury (A–F) and BRB breakdown (G, H). A–D, CNTF (0.5 μg) was injected 4 d after TMX treatment in one eye and the contralateral eye received BSS containing the same amount of BSA in each mouse. PNA staining was performed 6 d later. E, Quantitative analysis of PNA-stained retinal whole mounts. p < 0.01, CNTF versus BSS in TG mice. F, TUNEL for photoreceptor apoptosis. CNTF or BSS was injected 1 d after TMX treatment and TUNEL was performed 6 d after intravitreal injection. †p < 0.05, CNTF versus BSS. G, Quantitative analysis of retinal permeability to fluorescence-labeled dextran. CNTF was injected 4 d after TMX treatment and permeability was measured 7 d later. *p < 0.01, WT versus TG. H, Effects of CNTF on established retinal vascular leakage. FA was performed to confirm the development of intense focal vascular leakage 4 months after Müller cell ablation and CNTF was injected 1 week later. Retinal vascular leakage was monitored by FA at 5 and 12 d after CNTF injection. Scale bars: A–D, 100 μm.