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. 2014 Jan 22;77(2):324–336. doi: 10.1111/bcp.12116

Table 2.

Efficacy of combined pharmacotherapies for smoking cessation. U.S. Public Health Service clinical practice guideline meta-analysis

Combination therapies Number of arms Estimated OR (95% CI)
Nicotine patch (long term, >14 weeks) + ad lib NRT 3 3.6 (2.5, 5.2)
Nicotine patch + bupropion SR 3 2.5 (1.9, 3.4)
Nicotine patch + nortriptyline 2 2.3 (1.3, 4.2)
Nicotine patch + inhaler 2 2.2 (1.3, 3.6)

Adapted from The Clinical Practice Guideline Treating Tobacco Use and Dependence 2008 Update Panel, Liaisons, and Staff [3]. CI, confidence interval; NRT, nicotine replacement therapy; OR, odds ratio; SR, sustained release.