Table 3.

Comparison of HBIG and Nucleos(t)ides

	HBIG	Nucleos(t)ides
Administration	Intravenous or intramuscular	Oral
Setting	Office	Home
Standardization	No	Yes
Frequency	Daily for first week, then monthly	Daily
Adverse effects	Injection site reactions	None Renal function? Lactic acidosis?
Resistance	Viral breakthrough with monotherapy	Yes, with first generation
Mechanism	Neutralize antigen	Inhibit viral replication
Monitoring	Anti-HBs titers	Renal function
Costs	$$$	$$

Anti-HBs, hepatitis B surface antibody; HBIG, hepatitis B immunoglobulin.