Efflux ratio was greater in participants with both diabetes and increased triglyceride levels compared to participants with diabetes but without increased triglycerides (1a, p = 0.009, n=71). The efflux results were normalized to a standard pool. In contrast, HDL cholesterol levels were lower in subjects with both diabetes and increased triglyceride levels compared to participants with diabetes but without increased triglycerides (1b, p=0.04, n=72). These findings highlight the discrepancy between HDL cholesterol and ABCA-1 mediated efflux in hypertriglyceridemia. DM: type 2 diabetes, TG: Triglyceride levels between 150 mg/dL-500 mg/dL.