Fig. 3.

BOLD response for the whole brain analysis of positive trials and the relation to regulation efficacy. Top—Main effect of instruction revealed increased activity for enhance positive relative to attend positive trials in the (A) bilateral DMPFC/supplemental motor area, (B) left VLPFC, (C) left temporoparietal junction, (D) bilateral anterior VMPFC, (E) bilateral pgACC, (F) left ventral striatum and (G) right ventral striatum. Bottom—Positive regulation efficacy was positively correlated with the difference in percent signal change between the enhance vs attend positive conditions in the left ventral striatum (F) of the CTL group, but not the MDD group. All regions were thresholded at P < 0.005, two-tailed and corrected to P < 0.05 (FWE, k > 47). Active clusters are displayed on the averaged T1-weighted Talairach–Tournoux template (TT_avg152) in AFNI. Refer to Supplementary Figure 3 for bar plots of percent signal change.