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. Author manuscript; available in PMC: 2015 Mar 1.
Published in final edited form as: Drugs. 2014 Mar;74(4):403–413. doi: 10.1007/s40265-014-0182-z

Figure 1. Cross-talk between VEGFR, FGFR, and PDGFR signaling pathways.

Figure 1

In addition to VEGFR signaling, other pathways (eg, FGFR, PDGFR) have been shown to contribute to angiogenesis, possibly in concert with VEGFR. Republished with permission of the American Society for Clinical Investigation from Arbiser JL [83] © 2007.

Abbreviations: Akt, protein kinase B; Ang-2, angiopoietin-2; ERK, extracellular signal-regulated kinase; FGF, fibroblast growth factor, FGFR, fibroblast growth factor receptor; MEK, mitogen activated protein kinase kinase; PDGF, platelet-derived growth factor; PDGFR, platelet-derived growth factor receptor; PI3K, phosphatidylinositol-3-kinase; Raf, v-raf 1 murine leukemia viral oncogene homolog 1; Ras, retrovirus-associated DNA sequences; VEGF, vascular endothelial growth factor; VEGFR, vascular endothelial growth factor receptor.