Table 2. Structures and inhibitory activities (IC50) of flavonoid-based Cp-NanI inhibitors.
| Compound† | Structure | IC50 (µM) |
|---|---|---|
| Eriodictyol |
|
16.4 |
| 3′-O-Methyldiplacone |
|
14.3 |
| 4′-O-Methyldiplacone |
|
12.9 |
| Mimulone |
|
6.1 |
| Diplacone |
|
0.110 |
†
IUPAC nomenclature: eriodictyol, (2S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-chroman-one; 3′-O-methyldiplacone, 6-[(2E)-3,7-dimethylocta-2,6-dienyl]-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one; 4′-O-methyldiplacone, 6-[(2E)-3,7-dimethylocta-2,6-dienyl]-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one; mimulone, (2S)-6-[(2E)-3,7-dimethylocta-2,6-dienyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one; diplacone, 2-(3,4-dihydroxyphenyl)-6-[(2E)-3,7-dimethylocta-2,6-dienyl]-5,7-dihydroxy-2,3-dihydrochromen-4-one.