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. Author manuscript; available in PMC: 2015 Mar 13.
Published in final edited form as: Cell Rep. 2014 Feb 27;6(5):868–877. doi: 10.1016/j.celrep.2014.02.004

Figure 6.

Figure 6

Loss of RBP2 decreases tumor progression and metastasis in the MMTV-neu transgenic mice. (A) Kaplan-Meier tumor-free survival curves of the MMTV-neu transgenic mice with the indicated genotypes of Rbp2. N, animal number in each group; M, days of medium survival in each group. p < 0.0001 based on Log-rank (Mental-Cox) test. (B) Column scatter plot showing the number of lung metastatic nodules in the MMTV-neu transgenic mice with the indicated Rbp2 genotypes. (C) Incidence of lung metastasis of the MMTV-neu transgenic mice with the indicated Rbp2 genotypes. (D) Representative H&E-stained lung sections. Rbp2+/+:MMTV-neu mice (1, 3, 5) showed greater numbers of tumors in the lungs than Rbp2−/−:MMTV-neu mice (2, 4, 6), and the morphology of the tumor cells are similar (5, 6). Scale bars for panels 1–4 = 500 μm and for panels 5–6 = 100 μm.