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. 2014 Jan 22;23(11):3035–3044. doi: 10.1093/hmg/ddu020

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© The Author 2014. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Expression profiling of Sox9 and Sry expression in XY Map3k4^tm1Flv^/+, T^hp^/+ and transgenic T^hp^/+ embryonic gonads. (A and B) Relative expression levels of Sox9 for different genotypes (indicated by colour key beneath plots) between 15 ts and 29 ts stages. (C and D) Relative expression levels of Sry in gonads from the same genotypic classes and stages as in A and B. Note the delay in peak Sry expression in Map3k4^tm1Flv^/+ and T^hp^/+ gonads (C) and the enhanced, early Sry peak in transgenic T^hp^/+ gonads (D). Error bars indicate standard error mean. (E) Sox9 WMISH analysis at 20 ts in genotypes as indicated. (F) Sox9 WMISH analysis at 27 ts (∼12.5 dpc) in genotypes as indicated. (G–J) Anti-SOX9 antibody immunostaining of control B6.Y^B6 (G), control B6.Y^AKR (H), T^hp^/+ (I) and rescued (BAC transgenic) T^hp^/+ (J) gonadal tissue sections at 18 ts. (K–N) Anti-SRY antibody immunostaining of the same series of 18 ts gonadal sections as in G–J.