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. 2014 Jan 22;23(11):3035–3044. doi: 10.1093/hmg/ddu020

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© The Author 2014. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — A functional Map3k4 BAC transgene rescues abnormalities of XY gonad development in T^hp^/+ embryos. (A) WMISH analysis with Sox9 (upper row) and Foxl2 (lower row) of gonads at 14.5 dpc in control (+/+) and Map3k4-deficient (M4/M4) and transgenic Map3k4-deficient (M4/M4, BAC) embryos, revealing rescue of XY gonadal sex reversal in the latter class. (B) External genitalia of adult mice with genotypes indicated (upper row) and gross morphology of 14.5 dpc embryos with genotypes indicated (beneath). Note abnormal tails in T^hp^/+ animals. Lower panels show WMISH analyses with Sox9 (upper) and Stra8 (lower) of embryonic gonads at 14.5 dpc in genotypes indicated, revealing rescue of gonadal sex reversal in transgenic XY T^hp^/+ embryos. Arrows indicate clusters of Stra8-positive cells of varying sizes at the poles of the gonads.