Figure 4.

Effect of CTGF on protein levels for Collagen I and Collagen III in SKPs. A: Dose response of CTGF in SKPs. SKPs were treated with 20-500 ng/ml CTGF for 48 hours, and then protein levels for Collagen I and Collagen III were assessed by enzyme-linked immunosorbent assay (ELISA). B: The kinetics of CTGF responsiveness in differentiated cells. SKPs were treated with 100 ng/ml CTGF for 0-96 hours, and then protein levels for Collagen I and Collagen III were assessed by ELISA. All values indicates by an * are significantly different from control values (p<0.05). Abbreviations: SKPs, skin-derived precursors; CTGF, connective tissue growth factor.