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The diagnostic value of p16 hypermethylation in PPWs or serums was determined by means of receiver-operating characteristic (ROC) curves, of which the Aζ value of ROC curve was 0.899 for both (PPWs and serums) when compared to that in GC tissues. Both the value of p16 hypermethylation in PPWs/serums to diagnosis of GC progression were high.
