Table 1.
Clinicopathological correlations of p16 methylation in gastric cancer tissues, serums and preoperative peritoneal washes
| Clinicopathological parameters | Gastric cancer tissues | Serums | PPWs | ||||||
|---|---|---|---|---|---|---|---|---|---|
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| U | M | χ2 | U | M | χ2 | U | M | χ2 | |
|
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|
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| (p-value) | (p-value) | (p-value) | |||||||
| Gender | |||||||||
| Male | 7 | 46 | 0.088 | 13 | 40 | 2.833 | 14 | 39 | 1.510 |
| Female | 6 | 33 | (0.767) | 16 | 23 | (0.092) | 15 | 24 | (0.219) |
| Age (year) | |||||||||
| <60 | 10 | 58 | 0 | 22 | 46 | 0.083 | 22 | 46 | 0.083 |
| ≥60 | 3 | 21 | 1.000 | 7 | 17 | (0.773) | 7 | 17 | (0.773) |
| HP infection | |||||||||
| (-) | 8 | 42 | 0.315 | 18 | 32 | 1.018 | 17 | 33 | 0.312 |
| (+) | 5 | 37 | (0.574) | 11 | 31 | (0.313) | 12 | 30 | (0.577) |
| Lesion site | |||||||||
| Cardia | 4 | 26 | 0 | 8 | 22 | 0.486 | 8 | 22 | 0.486 |
| Body/Antrum | 9 | 53 | 1.000 | 21 | 41 | (0.486) | 21 | 41 | (0.486) |
| Tumor size | |||||||||
| <5 cm | 11 | 49 | 1.614 | 24 | 36 | 5.744 | 24 | 36 | 5.744 |
| ≥5 cm | 2 | 30 | (0.204) | 5 | 27 | (0.017) | 5 | 27 | (0.017) |
| Growth type | |||||||||
| Swell | 4 | 16 | 0.239 | 5 | 15 | 0.504 | 5 | 15 | 0.504 |
| Infiltration | 9 | 63 | (0.625) | 24 | 48 | (0.478) | 24 | 28 | (0.478) |
| Differentiation | |||||||||
| Well/Moderate | 11 | 51 | 1.233 | 22 | 40 | 1.383 | 21 | 41 | 0.486 |
| Poor | 2 | 28 | (0.267) | 7 | 23 | (0.240) | 8 | 22 | (0.486) |
| PLC | |||||||||
| (-) | 13 | 40 | 11.14 | 21 | 32 | 3.801 | 20 | 33 | 2.237 |
| (+) | 0 | 39 | (0.001) | 8 | 31 | (0.051) | 9 | 30 | (0.135) |
| Lymphatic invasion | |||||||||
| (-) | 13 | 54 | 4.163 | 24 | 43 | 2.111 | 23 | 44 | 0.900 |
| (+) | 0 | 25 | (0.041) | 5 | 20 | (0.146) | 6 | 19 | (0.343) |
| Vein invasion | |||||||||
| (-) | 11 | 58 | 0.269 | 24 | 45 | 1.360 | 24 | 45 | 1.360 |
| (+) | 2 | 21 | (0.604) | 5 | 18 | (0.244) | 5 | 18 | (0.244) |
| T stage | |||||||||
| T1/T2 | 9 | 29 | 4.870 | 18 | 20 | 7.532 | 17 | 21 | 5.238 |
| T3/T4 | 4 | 50 | (0.027) | 11 | 43 | (0.006) | 12 | 42 | (0.022) |
| Lymph node metastasis | |||||||||
| N0 | 13 | 33 | 15.139 | 19 | 27 | 4.079 | 18 | 28 | 2.467 |
| N1-3 | 0 | 46 | (<0.0001) | 10 | 36 | (0.043) | 11 | 35 | (0.116) |
| Distant metastasis | |||||||||
| M0 | 13 | 72 | 0.305 | 29 | 56 | 3.488 | 29 | 56 | 2.086 |
| M1 | 0 | 7 | (0.581) | 0 | 7 | (0.062) | 0 | 7 | (0.149) |
| Clinical stage | |||||||||
| I/II | 13 | 33 | 15.139 | 20 | 26 | 6.093 | 19 | 27 | 4.079 |
| III/IV | 0 | 46 | (<0.0001) | 9 | 37 | (0.014) | 10 | 36 | (0.043) |
PLC: peritoneal lavage cytology; PPWs: preoperative peritoneal washes; M: methylation; U: Unmethylation.