Table 5.
Univariate and multivariate COX regression analysis of the relationships between clinicopathological outcomes in LACSCC patients
| Variable | Subset | Hazard radio (95% CI) | p-value |
|---|---|---|---|
| Univariate analysis (n=132) | |||
| CD147 expression alone | high vs. low | 5.122 (2.563, 12.777) | <0.001 |
| GLUT-1 expression alone | high vs. low | 4.254 (1.910, 9.477) | <0.001 |
| CD147 AND GLUT-1 expression | CD147 and GLUT-1 dual high vs. CD147 and/or GLUT-1 low | 4.639 (2.365, 9.098) | <0.001 |
| Age | ≥50 years vs. <50 years | 0.872 | |
| FIGO stage | III+IVa vs. Ib+II | 2.610 (1.453, 4.689) | 0.001 |
| Histopathological grade | low+middle vs. high | 0.067 | |
| Tumor diameter | >4 cm vs. ≤4 cm | 3.366 (1.885, 6.012) | <0.001 |
| Combined chemotherapy (platinum-based) | yes vs. no | 0.446 | |
| Multivariate analyses (n=132) | |||
| CD147 expression alone | high vs. low | 0.092 | |
| GLUT-1 expression alone | high vs. low | 0.303 | |
| CD147 AND GLUT-1 expression | CD147 and GLUT-1 dual high vs. CD147 and/or GLUT-1 low | 4.114 (2.081, 8.134) | <0.001 |
| Age | ≥50 years vs. <50 years | 0.245 | |
| FIGO stage | III+IVa vs. Ib+II | 2.657 (1.462, 4.831) | 0.001 |
| Histopathological grade | Low+Middle vs. high | 0.057 | |
| Tumor diameter | >4 cm vs. ≤4 cm | 2.851 (1.583, 5.135) | <0.001 |
| Combined chemotherapy (platinum-based) | yes vs. no | 0.375 |
CI = confidence interval.