Figure 2.

TET2 Mutation types and distribution in CMML samples. Nine missense mutations within the two evolutionarily conserved regions (black boxes), 14 nonsense mutations (red boxes), 23 frameshift mutations (blue ovals) and three potential splice site mutations (orange ovals) in 27 of 39 patients (69.2%) at an average of 1.38 mutations per patient. Four of these mutations could be detected independently in multiple patients.