Table 1.
Clinicopathological characteristics of the reported sporadic hemangioblastomas in the retroperitoneum
Case | Age (y)/Sex | Gross features | VHL | Histological features | Immunohistochemical staining (positive) | Follow-up | References |
---|---|---|---|---|---|---|---|
1 | 47/M | solid and cystic component | – | spindled to plump stromal cells, admixed with epithelioid, lipid-filled multi-vacuolated cells; nuclear pleomorphism; lack of mitoses | vimentin, calponin, Leu7, S100, NSE | NED/NA | [2] |
2 | 71/F | solid, without a large cystic component | – | cytoplasm amphophilic to clear; round with delicate chromatin; lack of mitoses | inhibin-a-(focal), S100, Vimentin, CD57, CA IX, NSE; brachyury (weak) | NED/4 y | [5] |
3 | 59/M | solid, without a large cystic component | – | pale cytoplasm exhibiting occasional lipid droplets; irregularly nuclei; delicate chromatin; nuclear pleomorphism; lack of mitoses | inhibin-a, S100, NSE, CD56, Vimentin | NED/2 y | present |
F, female; M, male; NA, not available; NED, no evidence of disease; VHL, von Hippel-Lindau disease; y, years.