Plasma (A) and urinary (B) cysteinyl leukotriene concentrations in patients with chronic obstructive pulmonary disease (COPD, filled circles, n = 9 for plasma and n = 8 for urine samples) and without chronic obstructive pulmonary disease (non-COPD, open circles, n = 10) at 4 major interventional phases: before sternotomy (Baseline), at the end of cardiopulmonary bypass with continued extracorporeal circulation (End CPB), after cardiopulmonary bypass but before chest closure (After CPB), and 2 hours after intensive care unit admission (ICU). Horizontal bars represent median values. Single asterisk indicates P<.05; double asterisk indicates P<.01; triple asterisk indicates P<.001. P values are derived from 2-way analysis of variance with repeated measurements, with Bonferroni adjustments for multiple comparisons.