Table 3.

Multivariate analysis of clinicopathologic parameters in 732 cases of de novo DLBCL with R-CHOP regimen

	OS			PFS
	HR	95% CI	P value	HR	95% CI	P value
Age >60	1.697	1.090–2.642	0.019	1.525	0.934–2.491	0.092
Gender	0.848	0.596–1.206	0.358	0.975	0.670–1.418	0.894
B symptoms	1.116	0.771–1.615	0.561	1.193	0.802–1.774	0.385
ECOG 2	1.936	1.244–3.012	0.003	1.738	1.073–2.816	0.025
Stage III or IV	2.757	1.615–4.708	<0.001	2.552	1.445–4.509	0.001
Extranodal sites ≥2	1.603	1.038–2.476	0.033	1.794	1.112–2.894	0.017
Serum LDH, Elevated	1.477	0.974–2.240	0.066	1.724	1.087–2.732	0.021
IPI score ≥3	0.992	0.526–1.871	0.981	0.817	0.398–1.676	0.582
Size ≥6 cm	1.166	0.818–1.663	0.396	1.230	0.839–1.804	0.288
EBER +	1.590	0.691–3.658	0.276	1.480	0.642–3.411	0.358

CI; confidence interval, ECOG; Eastern Cooperative Oncology Group, IPI; International Prognostic Index