TABLE IV. Pearson Product Moment Correlation Analyses of HAA Toxicological Parameters and the Percent Reduction of Cellular ATP per pmol HAA in CHO Cells.

HAA toxicological parameters	CHO cell cytotoxic index (r)	CHO cell genotoxic index (r)	FHs cell genotoxic index (r)	Salmonella cytotoxic index (r)	Salmonella mutagenic potency (r)	CHO cell mutagenicity index (r)	Mouse terato- genicity (r)	GAPDH inhibition (r)
ATP % reduction per pmol HAAa	1.00	0.968	0.992	0.991	0.993	0.965	0.999	−0.986
CHO cell cytotoxic indexb		0.976	0.996	0.995	0.996	0.956	0.998	−0.990
CHO cell genotoxic indexc			0.992	0.993	0.991	0.868	0.959	−0.997
FHs cell genotoxic indexc				1.00	1.00	0.925	0.987	−0.999
Salmonella cytotoxic indexd					1.00	0.921	0.986	−0.999
Salmonella mutagenic potencyd						0.926	0.988	−0.999
CHO cell mutagenicity indexe							0.974	−0.906
Mouse teratogenicityf								−0.979
GAPDH inhibition kineticsg								1.00

^aCalculated from data presented in this study.

^bDerived as the reciprocal of the LC₅₀ concentration (× constant to generate whole numbers), data from [Plewa et al., 2010].

^cDerived as the reciprocal of the SCGE genotoxic potency value (× constant to generate whole numbers), data from [Plewa et al., 2010; Pals et al., 2011].

^dData from [Kargalioglu et al., 2002; Plewa et al., 2004].

^eData from [Zhang et al., 2010].

^fData from [Hunter et al., 1996].

^gThe average rate of GAPDH inhibition per μM monoHAA concentration derived from the slope of the inhibition curves for each monoHAA [Pals et al., 2011].