Table 1.
Gene Expression Level Changes vs. Concurrent Negative Controls after 30 min MonoHAA Exposure.
| IAA | BAA | CAA | |||||
|---|---|---|---|---|---|---|---|
| Gene Symbol | Functional Gene Group(s) | Fold Change | P-value | Fold Change | P-value | Fold Change | P-value |
| ALOX12 | Superoxide Metabolism | −2.286 | 0.015 | −1.972 | 0.013 | ||
| APOE | Antioxidant, Oxidative Stress Responsive | −1.725 | 0.040 | ||||
| CCL5 | Oxidative Stress Responsive | 3.588 | 0.001 | 2.424 | 0.004 | ||
| CYBA | Superoxide Metabolism | −1.519 | 0.045 | ||||
| CYGB | Peroxidase, Oxidative Stress Responsive | −1.941 | 0.038 | ||||
| DGKK | Oxidative Stress Responsive | 2.057 | 0.008 | ||||
| DHCR24 | Oxidative Stress Responsive | −1.832 | 0.050 | ||||
| DUOX1 | Peroxidase, Superoxide Metabolism, Oxidative Stress Responsive | −2.608 | 0.004 | −2.334 | 0.001 | ||
| EPHX2 | ROS Metabolism | 2.856 | 0.001 | 8.041 | < 0.001 | ||
| EPX | Peroxidase, Oxidative Stress Responsive | −1.857 | 0.017 | ||||
| GPX2 | Glutathione Peroxidase, Oxidative Stress Responsive | −4.396 | < 0.001 | ||||
| GSR | Antioxidant | −4.521 | <0.001 | −3.433 | 0.007 | ||
| KRT1 | Oxidative Stress Responsive | 3.549 | 0.008 | ||||
| LPO | Peroxidase, Oxidative Stress Responsive | 1.823 | 0.034 | 3.919 | 0.022 | ||
| MBL2 | Oxidative Stress Responsive | 2.702 | 0.038 | ||||
| MPO | Peroxidase, Oxidative Stress Responsive | 1.516 | 0.035 | 2.509 | 0.004 | ||
| NOS2A | Superoxide Metabolism | 7.000 | 0.002 | ||||
| NOX5 | Superoxide Metabolism | −1.782 | 0.042 | 3.901 | 0.004 | ||
| PIP3-E | Peroxidase, Oxidative Stress Responsive | 1.977 | 0.046 | 1.386 | 0.034 | ||
| PNKP | Oxidative Stress Responsive | −2.033 | 0.023 | −1.701 | 0.011 | ||
| PTGS2 (COX-2) | Peroxidase | 5.122 | < 0.001 | −2.410 | 0.004 | ||
| PXDNL | Peroxidase | −3.182 | 0.012 | ||||
| RNF7 | Oxidative Stress Responsive | 1.803 | 0.019 | ||||
| SCARA3 | Oxidative Stress Responsive | −1.840 | 0.013 | ||||
| SFTPD | ROS Metabolism | 1.973 | 0.017 | ||||
| SGK2 | Oxidative Stress Responsive | −2.422 | 0.007 | ||||
| SIRT2 | Oxidative Stress Responsive | −1.782 | 0.039 | −1.616 | 0.017 | ||
| STK25 | Oxidative Stress Responsive | −1.990 | 0.038 | ||||
| TPO | Peroxidase, Oxidative Stress Responsive | −2.339 | 0.012 | −2.377 | 0.002 | ||
| TXNDC2 | Antioxidant | 3.775 | 0.001 | −1.931 | 0.022 | ||
| TXNRD1 | Antioxidant | −1.543 | 0.049 | ||||