Figure 6.

Sequence alignment of N-acetylmannosamine kinase from three Gram-positive species of bacteria, three Gram-negative species of bacteria and three mammalian species. Highly conserved residues are highlighted in blue. Conserved amino-acid residues are numbered according to S. aureus. The ATP-binding motif is highlighted using a red box. The zinc-binding motif is highlighted using a purple box. Conserved secondary-structure elements are indicated above the alignment, where β-strands are depicted as orange arrows and α-helices are depicted as green wavy lines. Amino-acid positions are numbered down the right-hand side for all sequences. Mammalian amino-acid positions are numbered according to the position of the N-acetylmannosamine kinase domain within the bifunctional UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase.