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(a) Sialic acid catabolism. The enzymes involved in the uptake and subsequent catabolism of sialic acid are in bold. Lyase, N-acetylneuraminate lyase; kinase, N-acetylmannosamine kinase; epimerase (red), N-acetylmannosamine-6-phosphate 2-epimerase; deacetylase, N-acetylglucosamine-6-phosphate deacetylase; deaminase, glucosamine-6-phosphate deaminase. (b) The detailed reaction catalyzed by N-acetylmannosamine-6-phosphate 2-epimerase.
