Table 1.
Assessment scales evaluated in this study*
| Assessment scale |
Score | No. of items |
Component | Baseline SD |
Clinically meaningful change |
|---|---|---|---|---|---|
| NIH joint/fascia scale (range, 0-3) |
0: No symptoms 1: Mild tightness of arms or legs, normal or mild decreased ROM AND not affecting ADL 2: Tightness of arms or legs OR joint contractures, erythema thought due to fasciitis, moderate decrease ROM AND mild to moderate limitation of ADL 3: Contracture WITH significant decrease of ROM AND significant limitation of ADL (unable to tie shoes, button shirts, dress self etc.) |
1 | Tightness ROM ADL |
NA | 1 point† |
| Hopkins fascia scale (range, 0-3) |
0: Normal 1: Tight with normal areas 2: Tight 3: Tight, unable to move |
1 | Tightness | NA | 1 point† |
| P-ROM scale (range, 4-25) |
The summary of the 7-point wrist, shoulder, elbow scales plus the 4-point ankle scale (see Figure S1). |
4 | ROM | 2.1 | 1 point‡ |
| Lee muscle/joint subscale (range, 0-16) |
Summary of the following 4 items. Each item is rated at 0: not at all, 1: slightly, 2: moderately, 3: quite a bit, or 4: extremely. - Joint and muscle aches - Limited joint movement - Muscle cramps - Weak muscles |
4 | Symptom | 4.0 | 2 points‡ |
| Lee overall symptom scale (range, 0-100) |
30-item self-administered patient questionnaire specific to symptoms of chronic GVHD. |
30 | Symptom | 13.0 | 6.5 points‡ |
| 10-point global rating (range, 0-10) |
Chronic GVHD symptoms overall in the last week. Rated from 0 (not present) to 10 (as bad as you can imagine). |
1 | Symptom | NA | 2 points† |
| FACT-G | 27-item self-report questionnaire, which was validated for measuring response of chronic GVHD. |
27 | QOL | 16.2 | 8.1 points‡ |
| SF36-MCS | Mental component score from 36-item self-report questionnaire assessing health and functioning. |
36 | QOL | 10.9 | 5.5 points‡ |
| SF36-PCS | Physical component score from 36-item self-report questionnaire assessing health and functioning. |
36 | QOL | 9.8 | 4.9 points‡ |
| HAP-MAS | Maximum activity score from 94-item self-reported assessment of energy expenditure or physical fitness. |
94 | ADL | 12.7 | 6.4 points‡ |
| HAP-AAS | Adjusted activity score from 94-item self-reported assessment of energy expenditure or physical fitness. |
94 | ADL | 17.3 | 8.7 points‡ |
| Walk test | Total distance walked in 2 minutes. |
1 | Physical function |
128.4 | 64 feet‡ |
| Grip test | Grip strength in the dominant hand measured by a hydraulic dynamometer. Average of 3 measurements. |
1 | Physical function |
27.0 | 13.5 lbs‡ |
*
SD = standard deviation; ROM = range of motion; ADL = activities of daily living; NA = not applicable; P-ROM = photographic range of motion; GVHD = graft-versus-host disease; FACTG = Functional Assessment of Cancer Therapy-General; QOL = quality of life; SF36 = Short Form 36; MCS = mental component score; PCS = physical component score; HAP = Human Activities Profile; MAS = maximum activity score; AAS = adjusted activity score.
†
Derived from original design.
‡
Derived from half of standard deviation of baseline values