Figure 5. Validated splicing factor binding sites embedded in a dual-coding region.

The domain map of the canonical apoptosis-mediating surface antigen FAS is shown at the top, with domains marked by light purple and the only transmembrane region (TRM) marked by darker purple (residue boundaries assigned based on the UniProtKB). The boundaries of the region that overlaps the two splicing factor binding sites are provided, and the CDS corresponding to the given region is presented below the domain map. The two splicing factor binding sites are highlighted by yellow in the CDS with the names of the corresponding splicing factors indicated. The overlapping residues are similarly highlighted in the sequences of the two distinct protein isoforms. The predicted protein structural properties are indicated below as in Figure 3.