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. 2014 May 8;10(5):e1003615. doi: 10.1371/journal.pcbi.1003615

Figure 6. Ion channel and current fluctuations underlie waveform variability.

Figure 6

Ion channel and current fluctuations in an AP travelling along 0.2 µm diameter axons. All traces are aligned at the instant when the rising AP crosses half-peak. Data from the squid giant axon model is on the left, while the right plots show data from the rat hippocampal interneuron model. Shaded areas in A–D are the 3×SD envelope around the mean curve (dark curve). Light curves in A–D represent a sample of individual traces. (A) Membrane potential waveforms (B) Number of open Na+ (red) and K+ (blue) channels (C) Current flowing through Na+ (red) and K+ (blue) channels (D) Net membrane current (sum of Na+, K+ and leak) (E) SD of Na+ (red), K+ (blue) and net membrane (green) currents.