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. 2014 May 8;10(5):e1003615. doi: 10.1371/journal.pcbi.1003615

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© 2014 Neishabouri, Faisal

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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This model is used to estimate the vesicle release rate as a function of local transient Ca⁺⁺ concentration. Transition rates between states depend on Ca⁺⁺ local concentration in the vicinity of the vesicles. The release probability is higher the more Ca⁺⁺ ions are bound to the vesicle, according to a factor f = 31.3. The base rate constant I₊ is set to 2×10⁻⁴ s⁻¹.