Table 4.
Some biochemical variables in all subjects and in subjects with MetS according to NAFLD severity at ultrasound examination
| |
ALL SUBJECTS |
SUBJECTS WITH MetS |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
Variables |
N A F L D |
|||||||||
| Absent (n = 51) | Mild (n = 45) | Moderate (n = 88) | Severe (n = 80) | P | Absent (n = 10) | Mild (n = 21) | Moderate (n = 54) | Severe (n = 63) | P | |
| Urinary 8-iso-PGF2α (pg/mg creatinine) |
621,2 ± 125,9 |
674,3 ± 121,2 |
700,7 ± 108,4 |
751,3 ± 121,0 |
<,001 |
616,6 ± 213,2 |
700,2 ± 103,9 |
734,3 ± 34,5 |
761,9 ± 96,5 |
<,001 |
| sNOX2-dp (pg/ml) |
47,9 ± 9,9 |
52,9 ± 15,5 |
57,1 ± 13.3 |
60,0 ± 12,2 |
<.001 |
45,3 ± 14,2 |
56,0 ± 13,3 |
58,9 ± 12,6 |
60,4 ± 10.6 |
<,005 |
| Adiponectin (ng/ml) |
13,0 (8,0/15,0) |
10,0 (5,5/12,0) |
8,8 (6,0/13,5) |
6,0 (4,9/9,0) |
<,001 |
12,5 (5,0/13,9) |
9,4 (5,8/11,8) |
7,5 (5,0/11,1) |
6,0 (4,6/8,5) |
<,05 |
| Cytokeratin 18 (mIU/ml) |
136 (125/173) |
169 (129/185) |
176 (140/190) |
180 (168/182) |
<,001 |
147 (128/182) |
170 (132/188) |
180 (162/190) |
182 (175/195) |
<,05 |
| ALT (IU/L) |
18 (14/27) |
21 (17/34) |
26 (19/36) |
34 (25/45) |
<,001 |
16 (12,/22) |
26 (19/37) |
25,5 (17/36,3) |
32 (24/43) |
<,001 |
| GGT (IU/L) |
21 (14/30,5) |
23 (16/40,7) |
21 (16/35) |
33,50 (24/61) |
<,001 |
14 (11/25) |
25 (19/42) |
22 (16/34) |
34 (24/64) |
<,001 |
| HOMA_IR |
1,9 (1,3/2,3) |
2,5 (1,7/3,8) |
3,3 (2,2/5,4) |
5,2 (3,1/7,3) |
<,001 |
2,9 (1,1/3,8) |
2,9 (1,7/4,5) |
3,9 (2,9/5,9) |
5,6 (3,3/7,4) |
<,001 |
| Metabolic syndrome (%)* | 21,7 | 50,0 | 63,5 | 81,8 | <,001 | 100 | 100 | 100 | 100 | - |
*Defined according to ATPIII modified criteria (Ref. 30).