Table 3. Overrepresented transcription factor binding motifs near NR subfamily 2 promoter binding sites vs. those near NR2 subfamily binding sites lying >10 Kbp away from the closest gene.
| Modules with NR2F* | Prom. assoc. known1 | Expected (genome)2 | Over representation (genome)3 | Z-Score (genome)4 | |
| <1 Kbp | NRF1 | yes | 0.58 | 114.14 | 85.38 |
| ZF5F | yes | 1.34 | 47.79 | 53.72 | |
| E2FF | yes | 11.73 | 13.89 | 44.02 | |
| EGRF | yes | 8.8 | 12.39 | 33.62 | |
| XCPE | yes | 1.61 | 27.39 | 33.05 | |
| SP1F | yes | 9.25 | 10.59 | 29.01 | |
| HDBP | yes | 0.53 | 41.5 | 28.8 | |
| ZF02 | yes | 12.75 | 9.02 | 28.51 | |
| MTEN | yes | 1.44 | 22.96 | 25.91 | |
| CTCF | yes | 5.47 | 11.52 | 24.39 | |
| >10 Kbp | PTF1 | no | 2.09 | 6.22 | 7.2 |
| EREF | no | 6.09 | 3.94 | 7.05 | |
| NEUR | no | 6.7 | 3.13 | 5.33 | |
| HAND | no | 16.39 | 2.26 | 4.97 | |
| PERO | no | 9.16 | 2.62 | 4.74 | |
| NRSF | no | 3.39 | 3.54 | 4.41 | |
| HICF | no | 2.8 | 3.57 | 4.01 | |
| HESF | no | 4.27 | 3.04 | 3.98 | |
| IRXF | no | 6.43 | 2.49 | 3.58 | |
| NF1F | no | 5.63 | 2.31 | 2.9 |
*Transcription factor binding sites that are statistically overrepresented and lying within 1 Kbp of any NR2 subfamily member (ARP1, COUP, HNF4, HPF, PNR, TR2 or TR4) binding site; comparison is between the top 10 TF family motifs near NR2 promoter sites versus the top 10 TF family motifs near NR2 sites lying greater than 10 Kbp from the nearest gene.
TF families known to associate with promoters; yes or no.
Expected number of matches in an equally sized sample of the genomic background.
Overrepresentation against the genomic background: Fold factor of match numbers in input sequences compared to an equally sized sample in the background (i.e. found vs. expected).
Z-score [70] of overrepresentation against the genomic background: A Z-score of <−2 or >2 is statistically significant and corresponds to a p-value of about 0.05.