. 2014 May 8;9(5):e96696. doi: 10.1371/journal.pone.0096696

Table 1. Structural and catalytic motifs of Na⁺-NQR and RNF subunits.

Subunit/	TH	Cofactors	Substrate binding sites	Function
homologue
NqrA/RnfC		None (NqrA)/	None (NqrA)/	Structural? (NqrA)/
		2(4Fe-4S) and FMN (RnfC)	NAD⁺ (RnfC)	NAD⁺ reduction (RnfC)
NqrB/RnfD	9/8	Covalently -bound FMN and Riboflavin (?)	Ubiquinone (NqrB) and Sodium	Ubiquinone reduction (NqrB) and Sodium transport
NqrC/RnfG	2	Covalently -bound FMN
NqrD/RnfE	6		Sodium	Sodium transport
NqrE/RnfA	6		Sodium	Sodium transport
NqrF	1	FAD and 2Fe-2S	NADH	NADH oxidation
RnfB	1–2	6(4Fe-4S) and 2Fe-2S?	Ferredoxin	Ferredoxin oxidation

The cofactor, subunit composition and topology of Na⁺-NQR and RNF are reported previously [1], [25]. TH; Transmembrane Helices.

Table 1. Structural and catalytic motifs of Na+-NQR and RNF subunits.