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. 2014 May 13;38(6):784–792. doi: 10.1097/PAS.0000000000000185

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Copyright © 2014 by Lippincott Williams & Wilkins

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivitives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.

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A, Endoscopic findings at the 2-year follow-up for patient #1. A, Dome-like polypoid lesion measuring 1.0×0.6 cm with central ulceration was noted. B, Pathologic examination of endoscopic submucosal dissection specimen showed PGA with round nuclei and amphophilic cytoplasm, which is similar to that of the original biopsy. C, Direct transformation of PGA to invasive adenocarcinoma. D, Adenocarcinoma with invasion of glands into lamina propria. E, Loss of expression of MLH1 in adenocarcinoma and PGA.