Table 1. Review inclusion and exclusion criteria.

Inclusion Criteria

Studies of spontaneous/primary ICH patients

Studies of humans

Studies of adults (≥ 18 years of age)

Studies which measured any prognostic factor

Studies which measured END

Studies published in a peer reviewed journal

Studies in any language with an English abstract available

Primary studies of any design

Exclusion Criteria

A full-text copy of the study could not be obtained

A measure of risk (e.g. OR, RR, HR) for spontaneous/primary, adult ICH patients could not be estimated

Patients received an experimental or specific medical therapy or it was unclear

Patients received a surgical intervention before END was measured or it was unclear

The prognostic factor was not defined

END was not defined

The reliability of the measure used to define END was poor or unclear in the literature

The timing of the measurement of the prognostic variable or END was not defined or unclear

END denotes early neurologic deterioration.