Table 1. Genes differently methylated in case-control studies from leukemia subjects.
Gene | Studies | Overall OR (95% CI)a | P value |
CDKN2A | 12 | 3.53 [1.43, 8.73] | <0.01 |
GLIPR1 | 6 | 5.96 [2.29, 15.46] | <0.01 |
CDKN2B | 5 | 9.67 [2.48, 37.75] | <0.01 |
SHP1 | 5 | 29.27 [6.80, 125.99] | <0.01 |
ID4 | 5 | 45.24 [11.02, 185.78] | <0.01 |
DAPK1 | 3 | 28.85 [5.54, 150.14] | <0.01 |
CDKN1C | 3 | 6.16 [0.66, 57.72] | 0.11 |
RARA | 3 | 3.46 [0.65, 18.39] | 0.15 |
RUNX3 | 2 | 11.91 [1.45, 97.86] | 0.02 |
WIF1 | 2 | 14.15 [1.78, 112.81] | 0.01 |
MLH1 | 2 | 5.93 [0.27, 130.34] | 0.26 |
SOCS1 | 1 | 0.10 [0.01, 0.78] | 0.03 |
JUNB | 1 | 55.00 [1.86, 1622.60] | 0.02 |
ZO-1 | 1 | 45.00 [2.01, 1006.75] | 0.02 |
WNT5A | 1 | 121.51 [7.08, 2085.83] | <0.01 |
PER3 | 1 | 104.27 [6.33, 1718.74] | <0.01 |
CDH1 | 1 | 33.00 [1.78, 610.61] | 0.02 |
GRAF | 1 | 81.54 [4.82, 1379.56] | <0.01 |
SNRPN | 1 | 25.00 [1.39, 449.48] | 0.03 |
PLK2 | 1 | 67.34 [3.77, 1204.54] | <0.01 |
PRDX2 | 1 | 22.32 [1.32, 377.72] | 0.03 |
PLCD1 | 1 | 39.38 [2.21, 702.41] | 0.01 |
CEBPZ | 1 | 35.84 [2.12, 604.80] | 0.01 |
TP53 | 1 | 3.40 [0.16, 73.57] | 0.44 |
CEBPA | 1 | 2.53 [0.14, 47.18] | 0.53 |
FHIT | 1 | 4.80 [0.27, 85.35] | 0.29 |
SFRP1 | 1 | 1.54 [0.17, 14.09] | 0.70 |
CDH13 | 1 | 11.00 [0.46, 263.53] | 0.14 |
DLX3 | 1 | 1.66 [0.48, 5.65] | 0.42 |
IRF8 | 1 | 6.41 [0.34, 120.24] | 0.21 |
Odds ratio (OR) describes the likelihood of gene methylation observed in leukemia cases compared to controls.