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. 2014 May 8;9(5):e96822. doi: 10.1371/journal.pone.0096822

Table 1. Genes differently methylated in case-control studies from leukemia subjects.

Gene Studies Overall OR (95% CI)a P value
CDKN2A 12 3.53 [1.43, 8.73] <0.01
GLIPR1 6 5.96 [2.29, 15.46] <0.01
CDKN2B 5 9.67 [2.48, 37.75] <0.01
SHP1 5 29.27 [6.80, 125.99] <0.01
ID4 5 45.24 [11.02, 185.78] <0.01
DAPK1 3 28.85 [5.54, 150.14] <0.01
CDKN1C 3 6.16 [0.66, 57.72] 0.11
RARA 3 3.46 [0.65, 18.39] 0.15
RUNX3 2 11.91 [1.45, 97.86] 0.02
WIF1 2 14.15 [1.78, 112.81] 0.01
MLH1 2 5.93 [0.27, 130.34] 0.26
SOCS1 1 0.10 [0.01, 0.78] 0.03
JUNB 1 55.00 [1.86, 1622.60] 0.02
ZO-1 1 45.00 [2.01, 1006.75] 0.02
WNT5A 1 121.51 [7.08, 2085.83] <0.01
PER3 1 104.27 [6.33, 1718.74] <0.01
CDH1 1 33.00 [1.78, 610.61] 0.02
GRAF 1 81.54 [4.82, 1379.56] <0.01
SNRPN 1 25.00 [1.39, 449.48] 0.03
PLK2 1 67.34 [3.77, 1204.54] <0.01
PRDX2 1 22.32 [1.32, 377.72] 0.03
PLCD1 1 39.38 [2.21, 702.41] 0.01
CEBPZ 1 35.84 [2.12, 604.80] 0.01
TP53 1 3.40 [0.16, 73.57] 0.44
CEBPA 1 2.53 [0.14, 47.18] 0.53
FHIT 1 4.80 [0.27, 85.35] 0.29
SFRP1 1 1.54 [0.17, 14.09] 0.70
CDH13 1 11.00 [0.46, 263.53] 0.14
DLX3 1 1.66 [0.48, 5.65] 0.42
IRF8 1 6.41 [0.34, 120.24] 0.21
a

Odds ratio (OR) describes the likelihood of gene methylation observed in leukemia cases compared to controls.