Figure 1. DNA damage in breast cancer risk and progression (a) Tree modeling showing predictability power of combination of several biomarkers for invasive breast cancer risk.

Note that starting node in the tree model is fewer number than the total given for each risk cohort (40, 46 and 38). This reflects cases that were removed because all three biomarkers- Ki67, γ-H2AX and Caspase-3 -were not evaluable. Although this resulted in a smaller subset, this was necessary to better identify the distinct combination of the biomarkers by growing the tree based on completed data for all biomarkers of interest.