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. Author manuscript; available in PMC: 2014 May 9.
Published in final edited form as: Curr Pharm Des. 2013;19(18):3210–3214. doi: 10.2174/1381612811319180005

Figure 1. Illustrates pathways for APC/Ccdc20-mediated degradation of its major downstream targets as well as the identified Cdc20 upstream regulators.

Figure 1

The specific substrates of APC/Ccdc20 include Mcl-1, Cyclin A, Securin, p21, Cyclin B, and Nek2A. Several upstream proteins such as p53, Aurora A, RASSF1A, Emi1, Sirt2, APC15, and USP44, as well as various microRNAs including miR-449 and miR-494, have been recently found to regulate the expression of Cdc20.