Fig. 4.

VU0071063 is selective for SUR1-containing K_ATP channels. (A) Representative whole-cell patch-clamp experiment showing the effects of 50 μM VU0071063, 50 μM diazoxide, and 2 mM Ba²⁺ on K_ir6.2/SUR1 current at −120 mV. Note the differences in the kinetics of activation of VU0071063 and diazoxide. (B) Representative recording showing effects of 50 μM VU0071063, 50 μM pinacidil, and 2 mM Ba²⁺ on K_ir6.2/SUR2A currents. (C–F) Mean ± S.E.M./ current at −120 mV recorded from cells transfected with K_ir6.2/SUR1, K_ir6.1/SUR1, K_ir6.2/SUR2A, or K_ir6.1, SUR2A, respectively (n = 4–7).