VU0071063 inhibits glucose-stimulated β-cell calcium entry. (A) Two representative β cells loaded with FURA-2, displayed as a fluorescent ratio (340/380 nM) in response to 2 mM glucose (1), 14 mM glucose (2), 14 mM glucose + 10 μM VU0071063 (3), and 14 mM glucose (4). (B) Relative calcium responses of mouse islet cells following treatment with 2 mM glucose and as indicated by the conditions labeled above (black lines, n = 239 islet cells over 3 days and 13 plates of cells).