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. 2014 Apr 9;6(4):1654–1671. doi: 10.3390/v6041654

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© 2014 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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The filoviral transmembrane domain is necessary but not sufficient for tetherin antagonism. (A) Transduction of cells with pseudotypes bearing the indicated chimeric GPs was analyzed as described in Figure 1B. One representative experiment is displayed. Results were confirmed in at least five separate experiments. Error bars indicate standard deviation. (B) Tetherin antagonism of the indicated chimeric GPs was analyzed as described in Figure 1C. The results of a representative experiment are shown and were confirmed in at least four additional experiments.