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. 2014 Apr 3;15:107. doi: 10.1186/1745-6215-15-107

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Copyright © 2014 Eskandary et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Study flowchart of Part B (randomized controlled trial). Forty-four transplant recipients with late biopsy-proven antibody-mediated rejection (AMR) will be randomized to receive either bortezomib or placebo. The primary endpoint, the estimated glomerular filtration rate (eGFR), will be evaluated at 0, 6, 12, 18 and 24 months. Major secondary endpoints are the measured glomerular filtration rate (GFR), protein excretion, patterns of human leukocyte antigen reactivity and results obtained with 24-month protocol biopsies. Cr-EDTA, chromium ethylenediamine tetraacetic acid; DSA, donor-specific antibodies; MFI, mean fluorescence intensity.