Table 1.

Main inclusion and exclusion criteria – Part A

Inclusion criteria	1. Estimated glomerular filtration rate >20 ml/minute/1.73 m2
	2. ≥180 days post transplantation
	3. Age >18 years
	4. Written informed consent
Exclusion criteria	1. Acute rejection <1 month before screening
	2. Acute deterioration of graft function suspicious of acute rejection
	3. Documented intolerance of bortezomib, boron or mannitol
	4. Active viral, bacterial or fungal infection
	5. Active malignant disease
	6. Women who are pregnant or breastfeeding
	7. Serious medical or psychiatric illness
	8. Patients actively participating in another clinical trial