Table 2.
Association between phenotype of high myopia and genetic variants at 15q14 and 15q25 in the Han Chinese Population
| Chr/Mb | SNP [Minor Allele] | Case MAF | Allele Frequency | OR | P value | Adjusted P* | Genotype Frequency | OR | H-W P | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 15/35.0 |
rs634990[C] |
0.483 |
C |
T |
|
|
|
CC |
CT |
TT |
CC |
CT |
TT |
|
| |
HM cases |
|
450(43.4%) |
586(56.6%) |
0.88(0.76-1.04) |
0.27 |
0.54 |
102(19.7%) |
246(47.5%) |
170(32.8%) |
0.82(0.63-1.07) |
1.01(0.81-1.26) |
1.15(0.91-1.45) |
0.45 |
| |
Controls |
|
858(46.6%) |
984(53.4%) |
|
|
|
212(23.0%) |
434(47.1%) |
275(29.9%) |
|
|
|
0.11 |
| 15/79.5 |
rs8027411[G] |
0.441 |
G |
T |
|
|
|
GG |
GT |
TT |
GG |
GT |
TT |
|
| |
HM cases |
|
396(38.7%) |
626(61.3%) |
0.78(0.66-0.91) |
0.006 |
0.012 |
77(15.1%) |
242(47.4%) |
192(37.6%) |
0.66(0.50-0.89) |
0.99(0.80-1.23) |
1.32(1.06-1.66) |
0.96 |
| Controls | 839(44.9%) | 1029(55.1%) | 197(21.1%) | 445(47.6%) | 292(31.3%) | 0.26 | ||||||||
Adjusted P* is the P value modified by Bonferroni’s mutable tests correction.