Table 1.

Results of ANOVA modeling of the effect of time and strain on TCE metabolite concentrations in mouse serum.

Metabolite	Time point (hr)	Sample size (n)	Partial R2 (“heritability”)	Strain		Time
				F-statistic	p-Value	F-statistic	p-Value
TCA	2	37	0.25	0.53	0.890
	8	36	0.63	2.51	0.028
	24	23	0.76	2.65	0.066
	All		0.18	1.24	0.263	59.00	< 1 × 10–10
DCA	2	38	0.56	2.13	0.052
	8	36	0.58	2.09	0.061
	24	25	0.78	2.53	0.073
	All		0.22	1.69	0.075	6.19	0.003
DCVG	2	36	0.82	6.62	0.00001
	8	33	0.89	8.88	< 1 × 10–10
	24	12	1.00	1,376	0.021
	All		0.49	3.75	0.00009	40.50	< 1 × 10–10
DCVC	2	32	0.60	1.83	0.118
	8	19	0.72	1.27	0.404
	24	8	0.74	0.48	0.801
	All		0.34	1.41	0.189	1.53	0.229