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. 2014 May 10;5(2):156–163. doi: 10.5306/wjco.v5.i2.156

Table 3.

Downstream of tyrosine kinases (1-3) mRNA expression levels (mean ± SD)

Patient and tumour characteristics DOK-1 P DOK-2 P DOK-3 P
NPI
1 vs 2 2250 ± 4652 vs 3988 ± 7824 0.48 4.37 ± 10.32 vs 4.14 ± 12.26 0.950 6802 ± 18036 vs 37024 ± 127523 0.150
1 vs 3 2250 ± 4652 vs 942 ± 1395 0.19 4.37 ± 10.32 vs 1.57 ± 4.55 0.270 6802 ± 18036 vs 9808 ± 19782 0.600
2 vs 3 3988 ± 7824 vs 942 ± 1395 0.21 4.14 ± 12.26 vs 1.57 ± 4.55 0.420 37024 ± 127523 vs 9808 ± 19782 0.210
Tumour grade
1 vs 2 1346 ± 2587 vs 3886 ± 6155 0.18 0.651 ± 1.837 vs 4.63 ± 12.49 0.190 1259 ± 2797 vs 37803 ± 126737 0.084
1 vs 3 1346 ± 2587 vs 2100 ± 5520 0.58 0.651 ± 1.837 vs 4.23 ± 10.15 0.092 1259 ± 2797 vs 8954 ± 23276 0.022
2 vs 3 3886 ± 6155 vs 2100 ± 5520 0.37 4.63 ± 12.49 vs 4.23 ± 10.15 0.910 37803 ± 126737 vs 8954 ± 23276 0.170
TNM
1 vs 2 2507 ± 4800 vs 3553 ± 7084 0.62 6.62 ± 13.46 vs 1.195 ± 3.782 0.052 26175 ± 101693 vs 4508 ± 9938 0.100
1 vs 3 2507 ± 4800 vs 0.782 ± 1.38 0.01 6.62 ± 13.46 vs 0.00562 ± 0.00942 0.015 26175 ± 101693 vs 16879 ± 39061 0.640
1 vs 4 2507 ± 4800 vs 626 ± 1252 0.11 6.62 ± 13.46 vs 0.00001 ± 0.00001 0.015 26175 ± 101693 vs 83.2 ± 80.9 0.050
2 vs 3 3553 ± 7084 vs 0.782 ± 1.38 0.07 1.195 ± 3.782 vs 0.00562 ± 0.00942 0.190 4508 ± 9938 vs 16879 ± 39061 0.440
2 vs 4 3553 ± 7084 vs 626 ± 1252 0.15 1.195 ± 3.782 vs 0.00001 ± 0.00001 0.190 4508 ± 9938 vs 83.2 ± 80.9 0.014
3 vs 4 0.782 ± 1.38 vs 626 ± 1252 0.39 0.00562 ± 0.00942 vs 0.00001 ± 0.00001 0.320 16879 ± 39061 vs 83.2 ± 80.9 0.300
Survival
DF vs LR 1839 ± 4089 vs 1957 ± 2149 0.95 3.94 ± 8.96 vs 0.00001 ± 0.00001 0.009 18203 ± 86910 vs 16027 ± 40813 0.910
DF vs DR 1839 ± 4089 vs 12051 ± 17043 0.55 3.94 ± 8.96 vs 0.00246 ± 0.00349 0.009 18203 ± 86910 vs 11083 ± 22940 0.620
DF vs DR 1839 ± 4089 vs 3023 ± 6758 0.72 3.94 ± 8.96 vs 5.93 ± 17.43 0.750 18203 ± 86910 vs 21264 ± 60618 0.880

DOK: Downstream of tyrosine kinase; NPI: Nottingham Prognostic Index; DF: Disease Free; LR: Local Recurrence; DR: Distant Recurrence.